abstract：:Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors characterized by mutations of KIT or PDGFRA. The objectives of this study were to evaluate BRAF mutations in GISTs and then to correlate BRAF mutational status in the tumor with clinical parameters, with B-raf expression, and with activation of some cellul...

journal_title：American journal of clinical pathology

authors： Hostein I,Faur N,Primois C,Boury F,Denard J,Emile JF,Bringuier PP,Scoazec JY,Coindre JM

更新日期：2010-01-01 00:00:00

abstract：:Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells. Our objective was to assess whether the pRb-mediated HPV-suppressive effect of PAI-2 in cancer cell lines has implications in the outcome of HPV infections. Cervical biop...

journal_title：American journal of clinical pathology

authors： Syrjänen S,Naud P,Sarian L,Derchain S,Roteli-Martins C,Longatto-Filho A,Tatti S,Branca M,Erzen M,Hammes LS,Costa S,Syrjänen K

更新日期：2009-12-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) expresses pan-B-cell antigens and is usually CD5+/CD10-/CD23-/FMC7+. In this study, we evaluated 52 patients with confirmed diagnoses of MCL and identified variant immunophenotypes in 21 patients (19/48 classical and 2/4 variant MCLs), including CD5- in 6 (12%) of 52, CD10+ in 4 (8%) of 50, ...

journal_title：American journal of clinical pathology

authors： Gao J,Peterson L,Nelson B,Goolsby C,Chen YH

更新日期：2009-11-01 00:00:00

abstract：:Location-guided screening in cervical cytology offers a potentially significant advance over routine manual screening. A prospective, 2-armed, masked clinical trial of the BD FocalPoint GS Imaging System using SurePath slides (BD Diagnostics-TriPath, Burlington, NC) compared routine manual screening and quality contro...

journal_title：American journal of clinical pathology

authors： Wilbur DC,Black-Schaffer WS,Luff RD,Abraham KP,Kemper C,Molina JT,Tench WD

更新日期：2009-11-01 00:00:00

abstract：:We studied the expression of cytokeratin (CK) 7, CK20, CDX-2, and p16 in 119 cervical adenocarcinomas (65 usual type [50 invasive; 15 in situ], 37 intestinal type [21 invasive; 16 in situ], 10 endometrioid, 5 adenosquamous, and 2 signet-ring carcinomas) in comparison with 55 cases of rectal adenocarcinomas. The percen...

journal_title：American journal of clinical pathology

authors： Saad RS,Ismiil N,Dubé V,Nofech-Mozes S,Khalifa MA

更新日期：2009-10-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLs) have been implicated in atherogenesis. We studied 344 patients with acute coronary syndromes; approximately 40% were aPL+ in 1 or more tests and 60% aPL-. In 215 patients, coronary artery disease (CAD) was angiographically documented, with 43.7% positive for aPL vs 34.9% of patients ...

journal_title：American journal of clinical pathology

authors： Greco TP,Conti-Kelly AM,Greco T Jr,Doyle R,Matsuura E,Anthony JR,Lopez LR

更新日期：2009-10-01 00:00:00

abstract：:We report 2 cases of splenic postchemotherapy histiocyte-rich pseudotumor. Each patient had a history of diffuse large B-cell lymphoma, treated with multiagent chemotherapy. Computed tomography scans performed on both patients showed splenic masses. A positron emission tomography scan performed on 1 patient showed inc...

journal_title：American journal of clinical pathology

authors： Chandra P,Wen YH,Tuli S,Raphael BG,Amorosi EL,Medeiros LJ,Ibrahim S

更新日期：2009-09-01 00:00:00

abstract：:Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile cutaneous mastocytosis) to highly aggressive neoplasms like mast cell leukemia. Princi...

journal_title：American journal of clinical pathology

authors： Horny HP

更新日期：2009-09-01 00:00:00

abstract：:We optimized fluorogenic thrombin-generation assays with regard to sample volume, calibration, analytic corrections, and activation reagents. Lower sample volumes (40 vs 80 microL) were associated with better recovery of thrombin activity, lower interference due to absorbance of light, and higher total thrombin genera...

journal_title：American journal of clinical pathology

authors： Chandler WL,Roshal M

更新日期：2009-08-01 00:00:00

abstract：:Session 1 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology focused on chronic myelogenous leukemia, BCR-ABL1+ (CML). CML is a myeloproliferative neoplasm arising at the level of a pluripotent stem cell and consistently associated with the BCR-ABL1 fusion gene. CML most ...

journal_title：American journal of clinical pathology

authors： Vardiman JW

更新日期：2009-08-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is recognized as 2 distinct diseases: anaplastic lymphoma kinase (ALK)+ ALCL and ALK- ALCL. ALK+ ALCL occurs in younger patients and has a better prognosis. Human T-cell lymphotropic virus (HTLV-1) is linked to the development of adult T-cell leukemia/lymphoma (ATLL), which freque...

journal_title：American journal of clinical pathology

authors： Gualco G,Chioato L,Weiss LM,Harrington WJ Jr,Bacchi CE

更新日期：2009-07-01 00:00:00

abstract：:The diagnosis of myeloid leukemia cutis can be difficult, particularly in the context of an initial skin biopsy with a malignant hematopoietic neoplasm. We studied the immunohistochemical characteristics of 33 cases of myeloid leukemia cutis diagnosed at Stanford University Medical Center, Stanford, CA, 1996-2007, and...

journal_title：American journal of clinical pathology

authors： Cronin DM,George TI,Sundram UN

更新日期：2009-07-01 00:00:00

abstract：:This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregati...

journal_title：American journal of clinical pathology

authors： Paniccia R,Antonucci E,Maggini N,Romano E,Gori AM,Marcucci R,Prisco D,Abbate R

更新日期：2009-06-01 00:00:00

abstract：:Micropapillary lung adenocarcinoma (MPA) has been reported as an aggressive variant of adenocarcinoma, frequently manifesting at high stage with a poor prognosis. We analyzed the clinical and molecular profile of 15 primary MPAs for K-ras, EGFR, and BRAF mutations and performed fluorescence in situ hybridization for E...

journal_title：American journal of clinical pathology

authors： De Oliveira Duarte Achcar R,Nikiforova MN,Yousem SA

更新日期：2009-05-01 00:00:00

abstract：:After the March 2004 implementation of American Association of Blood Banks standards regarding platelet bacterial detection, we began quantitative glucose screening of whole blood-derived platelets (WB-P). The glucose level was measured immediately before component release--often storage day 4 or 5--using the Glucomet...

journal_title：American journal of clinical pathology

authors： McKane AV,Ward N,Senn C,Eubanks J,Wessels L,Bowman R

更新日期：2009-04-01 00:00:00

abstract：:Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression durin...

journal_title：American journal of clinical pathology

authors： Maeshima AM,Taniguchi H,Nomoto J,Maruyama D,Kim SW,Watanabe T,Kobayashi Y,Tobinai K,Matsuno Y

更新日期：2009-03-01 00:00:00

abstract：:Factitious laboratory results often lead to unnecessary testing or treatment. This brief review of factitious biochemical results due to preexisting hematologic conditions focuses on the mechanisms underlying the factitious results and suggests ways to prevent them. An observant pathologist identifies these errors, in...

journal_title：American journal of clinical pathology

authors： Dalal BI,Brigden ML

更新日期：2009-02-01 00:00:00

abstract：:In this study, I have estimated the percentage of tumor by visual estimate in 447 prostatectomy specimens from American Veterans Affairs patients and related this measurement to overall survival. Although percentage of tumor was significantly related to the serum prostate-specific antigen level, tumor stage, and Gleas...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2009-01-01 00:00:00

abstract：:Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purifie...

journal_title：American journal of clinical pathology

authors： Han XY,Seo YH,Sizer KC,Schoberle T,May GS,Spencer JS,Li W,Nair RG

更新日期：2008-12-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposi...

journal_title：American journal of clinical pathology

authors： Rossi G,Andreani A,Morandi P,Marchioni A,Corradini P,Cappiello G,Bortolotti M,Qosja A,Manzini C,Ferri C,Richeldi L,Cavazza A

更新日期：2008-12-01 00:00:00

abstract：:Chemotherapy is a well-established therapeutic approach for several malignancies, but its clinical efficacy is often limited by its related cardiotoxicity, which leads to cardiomyopathy, possibly evolving into heart failure. To detect cardiac damage, the adopted diagnostic approach is the estimation of left ventricula...

journal_title：American journal of clinical pathology

authors： Dolci A,Dominici R,Cardinale D,Sandri MT,Panteghini M

更新日期：2008-11-01 00:00:00

abstract：:Malignant mesothelioma is increasing in incidence worldwide, including in Japan. However, the accurate pathologic diagnosis of pleural or peritoneal mesothelioma (PM) is sometimes difficult if adequate histologic and immunohistochemical analyses are not undertaken. The aim of this study was to identify a useful antibo...

journal_title：American journal of clinical pathology

authors： Takeshima Y,Amatya VJ,Kushitani K,Inai K

更新日期：2008-11-01 00:00:00

abstract：:The purpose of our study was to improve the quality of care in an emergency department (ED) as measured by length of stay (LOS), total turnaround time (TAT) for laboratory result reporting, and the blood culture contamination rate. Data were included for patients who had at least 1 of 5 laboratory tests performed as p...

journal_title：American journal of clinical pathology

authors： Sheppard C,Franks N,Nolte F,Fantz C

更新日期：2008-10-01 00:00:00

abstract：:The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results ...

journal_title：American journal of clinical pathology

authors： Rubio CA,Orrego A,Höög A,Porwitz A,Petersson F,Elmberger G,Glaessgen A,Eriksson E,Kanter L,Jaremko G,Egevad L,Laforga J,Liljefors M,Löfdahl B,Norman P,Larsson O,Wanat R,Wejde J,Zickert P,Björk J,Caini S,Palli D

更新日期：2008-09-01 00:00:00

abstract：:Platelet refractoriness is caused by HLA antibodies and platelet-specific antibodies. Current methods used to detect antiplatelet antibodies have limitations. Solid phase red cell adherence (SPRCA) lacks sensitivity and requires a second assay using chloroquine-treated intact platelets to specify the response due to a...

journal_title：American journal of clinical pathology

authors： Vongchan P,Nawarawong W,Linhardt RJ

更新日期：2008-09-01 00:00:00

abstract：:The diagnostic value of glypican 3 (GPC3) immunostaining on needle biopsy specimens has not been well assessed. In this study, 120 liver needle biopsy specimens, including 46 from cirrhotic livers and 74 hepatocellular carcinomas (HCCs), were immunohistochemically examined for expression of GPC3. The results showed st...

journal_title：American journal of clinical pathology

authors： Anatelli F,Chuang ST,Yang XJ,Wang HL

更新日期：2008-08-01 00:00:00

abstract：:Delta checking is a laboratory information system (LIS)-based tool that detects patient and laboratory quality control errors. By using hemoglobin A1c (HbA1c) data, we developed a novel approach to summarizing and presenting patient Delta values to address limitations of current Delta check algorithms. Delta values we...

journal_title：American journal of clinical pathology

authors： Tran DV,Cembrowski GS,Lee T,Higgins TN

更新日期：2008-08-01 00:00:00

abstract：:Transketolases link the Embden-Meyerhof pathway to the pentose phosphate pathway. An influence of p-Akt on this metabolism was described. This study was performed to compare the expression of transketolase-like 1 (TKTL1) and p-Akt in glioblastoma multiforme (GBM) and other astrocytic gliomas (AGs, grades II and III). ...

journal_title：American journal of clinical pathology

authors： Völker HU,Hagemann C,Coy J,Wittig R,Sommer S,Stojic J,Haubitz I,Vince GH,Kämmerer U,Monoranu CM

更新日期：2008-07-01 00:00:00

abstract：:Centerin (SERPINA9/GCET1) is a protease inhibitor with expression restricted to germinal center B cells and lymphoid malignancies with germinal center B-cell maturation. Expression of the centerin gene transcript, along with bcl-6 and GCET2/HGAL, constitutes a molecular signature associated with a good prognosis in di...

journal_title：American journal of clinical pathology

authors： Paterson MA,Hosking PS,Coughlin PB

更新日期：2008-07-01 00:00:00

abstract：:DNA sequencing was used to confirm Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acids in endocervical swab samples. DNA in residues of the samples with positive results by 2 commercial kits was subjected to nested polymerase chain reaction (PCR) amplification. The nested PCR amplicons were used as templates...

journal_title：American journal of clinical pathology

authors： Lee SH,Vigliotti VS,Pappu S

更新日期：2008-06-01 00:00:00

abstract：:Little information has been reported describing antigen stability in plasma cell myeloma. In this study, the expression frequency and stability of 2 potential therapeutic targets, CD20 and CD52, along with the frequently aberrantly expressed CD56 antigen, were evaluated by flow cytometric analyses in 56 patients with ...

journal_title：American journal of clinical pathology

authors： Cao W,Goolsby CL,Nelson BP,Singhal S,Mehta J,Peterson LC

更新日期：2008-06-01 00:00:00

abstract：:We compared the morphologic findings of different types of marginal zone B-cell lymphoma (MZL) involving the bone marrow (BM), including 18 splenic (SMZL), 6 extranodal (mucosa-associated lymphoid tissue lymphoma), and 6 nodal cases. The median percentage of BM involvement was 15%, and multiple overlapping patterns of...

journal_title：American journal of clinical pathology

authors： Inamdar KV,Medeiros LJ,Jorgensen JL,Amin HM,Schlette EJ

更新日期：2008-05-01 00:00:00

abstract：:We compared a rapid, point-of-care multimarker protocol with a single and serial troponin I (TnI)-only protocol in 5,244 patients admitted to the emergency department with chest pain. The diagnosis of acute myocardial infarction (AMI) was based on a doubling myoglobin level accompanied by at least a 50% increase in th...

journal_title：American journal of clinical pathology

authors： Straface AL,Myers JH,Kirchick HJ,Blick KE

更新日期：2008-05-01 00:00:00

abstract：:We studied the magnitude, significance, and origin of an analytic bias that emerged between our point-of-care (POC) and our central laboratory (CL) methods for the measurement of hemoglobin A1c (HbA1c) and evaluated the analytic accuracy of 7 commonly used HbA1c methods relative to the National Glycohemoglobin Standar...

journal_title：American journal of clinical pathology

authors： Holmes EW,Erşahin C,Augustine GJ,Charnogursky GA,Gryzbac M,Murrell JV,McKenna KM,Nabhan F,Kahn SE

更新日期：2008-04-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT...

journal_title：American journal of clinical pathology

authors： Rausei-Mills V,Chang KL,Gaal KK,Weiss LM,Huang Q

更新日期：2008-04-01 00:00:00

abstract：:To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve the HER2 status of tumors demonstrating equivocal amplification. The present study was based on 17 breast core biopsy specimens demonstrating invasive carcinoma with equivocal HER2 amplification, defined as an HER2/chromo...

journal_title：American journal of clinical pathology

authors： Striebel JM,Bhargava R,Horbinski C,Surti U,Dabbs DJ

更新日期：2008-03-01 00:00:00

abstract：:Free testosterone (FT) measurement by equilibrium dialysis and liquid chromatography-tandem mass spectroscopy (LCMS/MS) is the "gold standard." We hypothesized that calculated FT values could substitute for measured values; compared FT results reported by Walter Reed Army Medical Center (WRAMC), Washington, DC, with r...

journal_title：American journal of clinical pathology

authors： DeVan ML,Bankson DD,Abadie JM

更新日期：2008-03-01 00:00:00

abstract：:We compared immunohistochemical expression of hepatocyte growth factor (HGF), c-met, alpha-inhibin, estrogen receptor (ER), and progesterone receptor (PR) in 10 pancreatic mucinous cystic neoplasms (PMCNs), 8 hepatobiliary cystadenomas (HBCs), and 6 simple liver cysts (SLCs).All HBCs and PMCNs were in women (mean ages...

journal_title：American journal of clinical pathology

authors： Lam MM,Swanson PE,Upton MP,Yeh MM

更新日期：2008-02-01 00:00:00

abstract：:Noncardiogenic pulmonary edema caused by transfusion has been observed for almost 60 years. Today, we know this entity as transfusion-related acute lung injury (TRALI). TRALI is an uncommon but potentially fatal adverse reaction to transfusion of plasma-containing blood components. It is typified by dyspnea, cough, hy...

journal_title：American journal of clinical pathology

authors： Cherry T,Steciuk M,Reddy VV,Marques MB

更新日期：2008-02-01 00:00:00

abstract：:Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

journal_title：American journal of clinical pathology

authors： Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

更新日期：2008-01-01 00:00:00